منابع مشابه
Planar cell polarity in Drosophila.
In all multicellular organisms, epithelial cells are not only polarized along the apical-basal axis, but also within the epithelial plane, giving cells a sense of direction. Planar cell polarity (PCP) signaling regulates establishment of polarity within the plane of an epithelium. The outcomes of PCP signaling are diverse and include the determination of cell fates, the generation of asymmetric...
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Scientists like to consider themselves as especially objective, but, however hard we try we cannot be very different from everyone else. Like them we helplessly absorb our knowledge, our perspectives, our valuation of whether something is exciting or boring from those around us. In this "extra view" I reflect on fashion, illustrating by a small discovery of ours, and discussing why it was not m...
متن کاملThe cell biology of planar cell polarity
Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between neighboring cells. Recent progress has been made toward understanding how protein transport, endocytosis, and intercellular interactions contri...
متن کاملCell packing influences planar cell polarity signaling.
Some epithelial cells display asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (PCP). A Frizzled-mediated feedback loop coordinates PCP between neighboring cells, and the cadherin Fat transduces a global directional cue that orients PCP with respect to the tissue axes. The feedback loop can propagate polarity across clones of cells that lack the g...
متن کاملPropagation of Dachsous-Fat Planar Cell Polarity
The Fat pathway controls both planar cell polarity (PCP) and organ growth. Fat signaling is regulated by the graded expression of the Fat ligand Dachsous (Ds) and the cadherin-domain kinase Four-jointed (Fj). The vectors of these gradients influence PCP, whereas their slope can influence growth. The Fj and Ds gradients direct the polarized membrane localization of the myosin Dachs, which is a c...
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ژورنال
عنوان ژورنال: Fly
سال: 2011
ISSN: 1933-6934,1933-6942
DOI: 10.4161/fly.5.2.14396